| cytochrome-b5 reductase | |||||||
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| Ribbon diagram of erythrocytic methemoglobin reductase with FAD bound. From PDB 1UMK. | |||||||
| Identifiers | |||||||
| EC number | 1.6.2.2 | ||||||
| CAS number | 9032-25-1 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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Cytochrome-b5 reductase (also known as methemoglobin reductase) is a NADH-dependent enzyme that converts methemoglobin to hemoglobin. It contains FAD and catalyzes the reaction:
NADH + H+ + 2 ferricytochrome b5 = NAD+ + 2 ferrocytochrome b5
The following four human genes encode cytochrome-b5 reductases:
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